Over the past six months, rimu has ~4X more commits to the project than I do, and then it is a steep drop off from there (other than a ton of individual css fixes by travis-jeans). So, it is not entirely a one person show, but it mostly is. Part of that is that rimu is just really quick. We will talk over an idea, and then he will implement it faster than I can even make the git branch.

Nothing to do with federation. piefed.zip decided not to make their modlog public. It’s an admin setting within piefed. IIRC, it isn’t an option in lemmy.

Oh man, give me a scientific issue any day of the week. I would much rather deal with some investigation rather than work on an IND, BLA, or MAA section to submit to an agency. I have tremendous respect for reg folks that can make sense of the agency guidance. Thank you for your service!

I work professionally in the field of pharmaceutical manufacturing, though mainly with liquid and lyophilized presentations. The issue talked about in this video, polymorphism and isomerization, would primarily just be an issue with drugs that are considered small molecules. Historically, that is most drugs…but that is changing as more and more other modalities are hitting the market.

Small molecules, especially in a dry powder, undergo lots of processes that would make cleaning with enough rigor to completely eliminate a polymorph extremely difficult. Things like milling, mixing, spray drying, and pressing are extremely energetic and intentionally disperse powder like crazy. The cleaning cycles for all this equipment are already extremely rigorous, often reducing contaminants to levels too low to measure and then undergoing sterilization cycles with vaporized hydrogen peroxide (VHP) between batches. However, when you are talking about autocatalysis like this, it only takes ppb-level contamination to propagate through the whole batch.

When you are talking about large molecules like biologics (antibodies, most vaccines, etc.), there are a whole bunch of other things that can go wrong, but not this. The most analogous thing I can think of would be a persistent viral contamination. Current good manufacturing practices (cGMP) should be able to alleviate this though, and it wouldn’t impact tech transfer to a different site like what happened in the video. Alternatively, I have worked on mAbs where each batch would measure the glycosylation state because it impacted activity. That is a post-translational modification process for that drug that some batches worked better than others, but we never really tracked down a root cause (before the program was killed).

Another case study that happened on a program I was working on was that we had a series of batches where the active ingredient (a mAb) was oxidized at a much higher rate than normal. Nothing about our process had changed, but it was a clear night/day difference that happened all of a sudden. After lots of testing and ruling things out, we managed to figure out that there were elevated levels of iron in our product. By sampling at each step of our process, we figured out that the iron was being introduced during two steps called bioburden reduction filtration and sterile filtration. You might notice that these are both unit operations where our drug passes through filter membranes (they were in fact the same filters). Ultimately, it turned out that the supplier of our filters had a contamination issue that impacted their filters from a certain lot and later. So, we were ultimately able to fix it, but I remember those reports being literally hundreds of pages of ruling stuff out before we finally figured out the root cause.

Hope that helps you feel better!

Also a former big fan of RIF and I found Boost a fairly easy transition.

There is an admin setting that requires a user to be logged in before viewing pages on the site. We keep that off normally, but we recently had it on for a couple of days because of over-aggressive scrapers.

I just checked in the admin panel and your user isn’t banned. It’s possible that you might be quite unlucky with a VPN exit node or something and are now on an IP that was previously subject to a ban. We tend to not use IP bans except in egregious cases, but those users also tend not to connect via their home connection.

Things you can try:

• Try clearing your browser cache for piefed.social. You want to remove any cookies that might be left in your browser from the site.
• If you are using a VPN try turning it off and clearing your browser cache. Basically trying to start fresh with a new IP address.
• If you aren’t using a VPN, try from a mobile device, third-party app, or one of our alternative frontends (photon, blorp)

Piefed does allow users the option to not federate their votes. So harvesting that data would mean needing local access to the infrastructure or snooping on traffic to/from your local instance.

Just to be clear, I think Skavau is proposing an idea, not talking about a feature that currently exists within PIeFed.

Overall, more fine-grained roles and permissions are a recurring topic that has come up in discussions. That is both among the developers and with other instance admins. I think being able to make some users be able to take some actions like clean up/assign flair or edit wiki pages without being given all the moderator powers would be a big improvement.

The really hard part of this comes when you introduce federation. You both need to give a user the ability to do the thing and also allow other instances to recognize that they have the permission to do that thing, or else their actions will not federate.

Edit: Seems like this is a lemmy problem in general with quotation marks in the spoiler summary block. If you are on a lemmy instance and put this into the markdown, it will render the same way:

::: spoiler "Quotes" get garbled  
That summary above is messed up.  
:::  

So, this isn’t a PieFed issue at all, but something to do with lemmy’s markdown to html conversion improperly url-escaping quotes when it is in a <summary> tag.

Ok, I was really confused about this since I couldn’t reproduce this at all. However, this seems to only apply to quotes that are in a spoiler header. I made a codeberg issue for this.

Growing up in the US, other responders are correct that school systems vary a lot depending on what state/district you live in. Over the course of my K-12 education, I attended 10 different schools across three states because my family moved a lot. There were times where I would switch schools and suddenly be way ahead in some subject and have completely skipped over some other topics. As an example, I never took a course in world history, but ended up having three separate US history courses because the different districts taught those subjects in different grades.

I do take issue with some of the commenters painting all US schools with a broad brush as terrible. There are excellent schools in the US and excellent school systems. As an example, I currently live in Massachusetts, and if you took it as its own country, it would be one of the best school systems in the world. In general, the states that prioritize education and pay teachers well end up with better educational outcomes. It’s not that surprising really, but a huge portion of the country seems to ignore that fact or spend money in less efficient ways.

My Ph.D. is in rheology and material science. One of the craziest papers I ever remember reading was about the non-Newtonian behavior of frog tongues and saliva. I still think about this paper from time to time. There was a sequence of pictures showing a frog tongue (removed from the rest of the frog) lying on a table, and then somebody touching it with an ungloved finger and showing how sticky it was as they retracted their finger. What they won’t get poor grad students to do…

Link to the paper (pdf warning).

discuss.online is doing it right. There is a significant overlap between discuss.online and lemmy.world’s admin teams, and I generally think they handle it about as well as could be expected of a general-purpose instance of their scale.

As for piefed, I think the primary things that help users filter their experience are the additional blocks that are at their disposal; blocking communities with a word in their name, blocking posts that match keywords, blocking posts that point to certain domains, etc. However, it can only help if a user actually goes through the effort of setting them up.

Alright, I need to step away to do actual work that pays the bill at this point, but wanted to drop what I found here before doing so.

• Summit seems to be 403-ing for piefed.social. However, I was able to log in to other piefed sites (feddit.online, piefed.ca, my dev instance) with Summit, so it’s probably just piefed.social I guess?
• I tried both Boost and Voyager and they were both able to log into piefed.social.
• I was able to confirm that Summit wouldn’t trip any of the user-agent related filtering in the codebase (to try to keep scrapers out of certain things).

My guess at this point is that there might be something wonky going on at the infrastructure/WAF-level. If so, then this status quo is going to stick around until @rimu@piefed.social can dive into it. My sysadmin skills are not the best when it comes to this kind of thing.

I see, so Summit is where the 403’s are coming from. I’ll do some testing on my end and see if I can figure it out.

Edit: confirm that Summit is giving a 403, but other apps are still working…investigating…

Mobile browser, or one of the apps (voyager, summit, interstellar, etc.)?

It’s unlikely to be an IP ban. Within the piefed software, an IP ban basically coincides with a site ban. At the infrastructure level, your IP may be banned because it was doing some pretty heavy DDOS’ing and got swept up that way. Since your user isn’t banned, try switching between a mobile network and a wifi connection to see if that resolves things since your IP would have changed.

Are you trying the mobile browser or one of the mobile apps? If it is the mobile browser, try clearing the site data for piefed (cookies, etc.). There have been some cases in the past where a browser’s local cache is not being refreshed properly and weird stuff starts to happen, like the CSRF tokens mismatching and whatnot.

My goodness, I hadn’t realized how big fedinsfw.app had become. It’s now easily the biggest piefed instance with almost 2x the MAU of piefed.social.

I’m pretty sure that’s what is happening and I am really looking forward to it.

For those out there poking the code, please disclose responsibly! Don’t just make a public post about a security vulnerability, reach out to the devs first to give them a chance to create a fix.