I use it for everything, because I connected my external monitors through the eGPU. https://wiki.archlinux.org/title/PRIME has a few methods for running only selected applications via the eGPU, but I haven’t tried them. Edit: See also https://wiki.archlinux.org/title/External_GPU#Xorg for eGPU specific setups.
The main reason for Ubuntu against Debian is the packages. For Ubuntu, they’re much newer, and with PPAs (launchpad.net), you can often get more and/or newer packages built by other users. For debian, good luck, you’re stuck with old packages (which is the intent of Debian stable, but not nice as a user, that’s for server)